Joint Arthroplasty: Implant Retrieval & Failure Analysis

The goal of implant retrieval analysis is to advance the understanding of implant performance by evaluation of changes to materials, surfaces, and condition of components after in vivo services. Ultimately, this information is useful to determine the factors that could increase implant lifespan. The retrieval analysis laboratory uses state-of-the-art techniques to analyze histopathology of periprosthetic tissues, gross and microscopic examination of fixation interfaces and evaluation of wear and damage to the implant surfaces.

The JVL Implant Retrieval Lab actively collaborates with multiple surgeons and institutions nationally and internationally. 

In conjunction with clinical information and imaging studies, retrieval observations and measurements advance understanding of important factors affecting fixation, stability and wear performance in the patient.

The JVL Implant Retrieval Lab has an extensive archive of retrieved joint replacements and associated tissues spanning four decades, covering several generations of evolving implant designs and concepts.

Current Research

  • Comprehensive analysis of metal-on-metal total hip replacement retrievals
  • The effect of hydroxyapatite coating on bone ingrowth and ongrowth in joint replacement implants
  • Comprehensive analysis of retrieved disc replacements for the cervical and lumbar spine
  • Analysis of biological reaction of periprosthetic tissues to wear debris and implant materials
  • Development and application of a standardized scale for quantification of periprosthetic tissue reactions (ALVAL Score)


  1. Park, S. H., Lu, Z., Hastings, R. S., Campbell, P. A., & Ebramzadeh, E. (2018). Five hundred fifty-five retrieved metal-on-metal hip replacements of a single design show a wide range of wear, surface features, and histopathologic reactions. Clinical Orthopaedics and Related Research, 476(2), 261.
  2. Yuan, N., Park, S. H., Luck Jr, J. V., & Campbell, P. A. (2018). Revisiting the concept of inflammatory cell‐induced corrosion. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106(3), 1148-1155.
  3. Campbell P, Park SH, Zoller S, Yousuf J, & Nelson SD. (2017). Solid corrosion products in the periprosthetic tissues of a distal femoral endoprosthesis used to treat osteosarcoma. Corrosion : Special Issue on Biocorrosion 73(12):1530-1537
  4. Campbell P, & Ebramzadeh E. ARMD and Presumed Dangerous!: Commentary on an article by Gulraj S. Matharu, et al.: “Blood Metal Ion Thresholds to Identify Patients with Metal-on-metal Hip Implants at Risk of Adverse Reactions to Metal Debris. An External Multicenter Validation Study of Birmingham Hip resurfacing and Corail-Pinnacle Implants”. 2017, Journal of Bone and Joint Surgery ;99(18)
  5. Kung MS, Campbell P, Markantonis J, Knutsen A, Ameri B, Park S-H, Ebramzadeh E: Histological characterization of chromium orthophosphate corrosion products from modular total hip replacements. Modularity and Tapers in total Joint Replacement Devices. STP1591, pp428-439. Greenwald AS, Kurtz SM, Lemons JE, Mihalko WM (Eds). ASTM International, West Conshohocken, PA, 2015.
  6. Kung M, Markantonis J, Nelson SD, & Campbell P. (2015).  The synovial lining and synovial fluid properties after joint arthroplasty. Special Issue: Tribological Performance of Artificial Joints.  Lubrication. 3(2), 394-412.
  7. Tan, T. L., Ebramzadeh, E., Campbell, P. A., Al-Hamad, M., & Amstutz, H. C. (2014). Long-term outcome of a metal-on-polyethylene cementless hip resurfacing. The Journal of Arthroplasty, 29(4), 802-807.
  8. Takamura, K. M., Amstutz, H. C., Lu, Z., Campbell, P. A., & Ebramzadeh, E. (2014). Wear analysis of 39 conserve plus metal-on-metal hip resurfacing retrievals. The Journal of Arthroplasty, 29(2), 410-415.
  9. K. De Smet, P. Campbell, C. Van Der Straeten: The Hip resurfacing Handbook. Woodhead Publishing, U.K., May 2013
  10. Van Der Straeten, C., Grammatopoulos, G., Gill, H. S., Calistri, A., Campbell, P. & De Smet, K. A. (2012)  “The 2012 Otto Aufranc award: The interpretation of metal ion levels in unilateral and bilateral hip resurfacing.” Clinical Orthopaedics and Related Research, 471(2): 377-85.
  11. Ebramzadeh, E., Campbell, P. A., Takamura, K. M., Lu, Z., Sangiorgio, S. N., Kalma, J. J., ... & Amstutz, H. C. (2011). Failure modes of 433 metal-on-metal hip implants: how, why, and wear. Orthopedic Clinics, 42(2), 241-250.
  12. Takamura, K. M., Yoon, J., Ebramzadeh, E., Campbell, P. A., & Amstutz, H. C. (2011). Incidence and significance of femoral neck narrowing in the first 500 Conserve® Plus series of hip resurfacing cases: a clinical and histologic study. Orthopedic Clinics, 42(2), 181-193.
  13. De Smet, K., De Haan, R., Calistri, A., Campbell, P. A., Ebramzadeh, E., Pattyn, C., & Gill, H. S. (2008). Metal ion measurement as a diagnostic tool to identify problems with metal-on-metal hip resurfacing. Journal of Bone and Joint Surgery, 90, 202-208.