Factors Affecting Fracture Healing

The JVL researchers have investigated interfragmentary motion on fracture healing under carefully controlled laboratory conditions. Specifically, the difference between applying axial motion alone or  shear motion on fracture healing has been studied. For this purpose, an in vivo model was designed and developed to simulate clinically relevant conditions specific to tissue healing of closed fractures.


The following methods are routinely used for the evaluation of fracture healing:

  • Imaging, including x-rays and quantitative computerized tomography (qCT)
  • Biomechanical testing, using small custom loading apparatuses and multi-axis load frames
  • Histological evaluation

The effects of blood supply on fracture healing have been evaluated using in vivo models. A Laser Doppler flowmeter was used to measure in vivo blood flow at the fracture site throughout the fracture healing period.



  1. Park, S.H. and Silva, M.  Neuromuscular Electrical Stimulation Enhances Fracture Healing: Results of an Animal Model.   J Orthop Res 22(2) 382-387, 2004
  2. Park, S.H., Silva M. Effect of pneumatic soft tissue compression of fracture healing in an animal model. J Bone Joint Surg 85A(8) 1446-1453, 2003
  3. Park, S.H., O’Connor, K. McKellop, H.: Interaction between Active Motion and Exogenous Transforming Growth Factor Beta (TGF-b1) during Tibial Fracture Repair, J Orthop Trauma 17(1): 2-10, 2003
  4. Park, S.H., Silva, M., Bahk, W.J., McKellop, H., Lieberman, J., Effect of repeated irrigation and debridement on fracture healing in an animal model, J. Orthop. Res. 20(6): 1197-1204, 2002
  5. Park, S.H., O'Connor, K., Sung, R., McKellop, H., Sarmiento, A. Comparison of healing processes in open osteotomy model and closed fracture model. J Orthop Trauma. 13(2):114-120, 1999
  6. Park, S.H., O'Connor, K., McKellop, H., Sarmiento, A. The influence of active shear or compressive motion on fracture healing. J Bone and Joint Surg. 80(A) 6: 868-878, 1998